Local translation in neuronal compartments: how local is local?

Local translation in neuronal compartments: how local is local?

Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localization of translational machinery, spatial spread of the newly translated proteins, and their site of action are carried out in specialized neuro...

Supplemental Information How Local Is the Local Field Potential?

Generalizing Local Translation Models

We investigate translation modeling based on exponential estimates which generalize essential components of standard translation models. In application to a hierarchical phrasebased system the simplest generalization allows its models of lexical selection and reordering to be conditioned on arbitrary attributes of the source sentence and its annotation. Viewing these estimates as approximations...

Anchoring Local Translation in Neurons

In probing how protein synthesis in neurons is coupled to extracellular stimuli, Tcherkezian et al. (2010) discover that the receptor protein DCC anchors components of the translation machinery at the plasma membrane. Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis.

How Good Is Local Type Inference?

A partial type inference technique should come with a simple and precise specification, so that users predict its behavior and understand the error messages it produces. Local type inference techniques attain this simplicity by inferring missing type information only from the types of adjacent syntax nodes, without using global mechanisms such as unification variables. The paper reports on our ...